The study was carried out in a total number of 65 patients of Waja-ul-Mafasil of either sex satisfying the criteria of American Rheumatism association. All the patients received treatment with coded Unani drugs UNIM-312 along-with local application of UNIM-304 for a period of 90 days after complete therapy of Munzij (UNIM-308), Mushil (UNIM-309) and Tabreed (UNIM-310) with Hijamah (cupping). Out of 65 cases 56 patients completed the study, 42 patients were sero-positive, 13 patients got complete remission, 35 patients got partially remission, 08 patients got no relief and 09 patients dropped out. No hepatotoxic and nephrotoxic side effects noticed during the course of study. The clinical and laboratory findings after treatment have shown that coded drugs possessed efficacy in the treatment of Waja-ul-Mafasil.